Programme
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Thursday, 20 May 2010 |
07:30 |
Bus Transfer from hotels |
08:00 |
Registration |
08:40 |
Opening |
Session 1 Chemical Biology in Europe and beyond (J. Quintana & K. Tasken) |
08:45 |
Keynote lecture
NIH Molecular Libraries Program: Integrative Technologies Enabling Biology and Chemistry as a Public Resource for Translational Research |
James Inglese (Bethesda, USA) |
09:30 |
Academic screening, challenges and new opportunities |
Phil Gribbon (Hamburg, Germany) |
10:00 |
Approaches to Drug Discovery for Tropical Diseases |
Ian Gilbert (Dundee, UK) |
10:30 |
Chemical Biology of Protein-Protein Interactions: Challenges and Opportunities |
Joe Lewis (Heidelberg, Germany) |
11:00 |
Coffee break |
Session 2 Chemical chaperones and Protein Aggregation (R. Frank & M. Hibert) |
11:30 |
Keynote lecture
Small molecule compounds: novel therapeutics for genetic diseases due to misfolding? |
Peter M.T. Deen (Nijmegen, Netherlands) |
12:15 |
Biased agonists pharmacochaperones of the V2 vasopressin receptor as potential therapeutic agents for nephrogenic diabetes insipidus |
Christiane Mendre (Montpellier, France) |
12:45 |
Two unrelated antiprion drugs isolated using a yeast-based assay are specific inhibitors of Ribosome-borne Protein Folding Activity (RPFA) |
Marc Blondel (Brest, France) |
13:15 |
Chemical Chaperones Modulate Protein Misfolding Pathways in Neurodegenerative Diseases |
Erich Wanker (Berlin, Germany) |
13:45 |
Lunch |
Session 3 New Challenges and Avenues (T. Nielsen & O. Kallioniemi)
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14:45 |
Keynote lecture
Drugging the cancer genome: Chemical probes and drugs in the clinic |
Paul Workman (London, UK) |
15:30 |
Chemical probes for systems biology |
Jordi Mestres (Barcelona, Spain) |
16:00 |
How to turn a protein kinase ON and OFF using the same switch: High resolution complex structure and allosteric effects of low molecular weight activators on the protein kinase PDK1 (selected from abstracts) |
Ricardo M. Biondi (Frankfurt, Germany) |
16:15 |
A boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation (selected from abstracts) |
Huib Ovaa (Amsterdam, Netherlands) |
16:30 |
Prospects and Challenges in Open Source Drug Discovery: Strategies to Conquer the Valley of Death (selected from abstracts) |
Rathnam Chaguturu (Kansas, USA) |
| 17:00 Poster and Czech beer session & BBQ |
Friday, 21 May 2010 |
8:30 |
Bus Transfer from hotels |
Session 4 Protein modifications (G. Superti-Furga & A. Levitzki) |
09:00 |
Keynote lecture
The interplay between phosphorylation and ubiquitylation in regulating innate immunity |
Sir Philip Cohen (Dundee, UK) |
09:45 |
Molecular targets, mechanisms and opportunities for combination therapies of multi-targeted kinase inhibitors |
Uwe Rix (Vienna, Austria) |
10:15 |
Open Access Chemical Probes for Epigenetic Proteins |
Tom Heightman (Oxford, UK) |
10:45 |
EGFR receptor guided delivery of long chain dsRNA |
Alex Levitzki (Jerusalem, Israel) |
11:15 |
Coffee break |
Session 5 New Challenges and Avenues (T. Nielsen, O. Kallioniemi) |
11:45 |
Combinatorial Chemistry for the Chemical Biology of the GPCR's |
Morten Meldal (Copenhagen, Denmark) |
12:15 |
Chemical and Biological Diversity: New Approaches to Synthesising Bioactive Small Molecules |
Adam Nelson (Leeds, UK) |
12:45 |
Small molecules as inhibitors of Interleukin 8 expression (selected from abstracts) |
Marc Reboll (Braunschweig, Germany) |
13:00 |
Synthetic Mimicry of Protein Binding Sites for the Exploration and Modulation of Protein-Protein Interactions (selected from abstracts) |
Jutta Eichler (Braunschweig, Germany) |
13:15 |
Lunch |
Session 6 Stem cell biology (P. Bartunek, K. Wennerberg ) |
14:15 |
Keynote lecture
Chemical Biology and Zebrafish |
Leonard I. Zon (Boston, USA) |
15:00 |
Targeting chromatin for transdifferentiation in the pancreas |
Stefan Kubicek (Cambridge, USA) |
15:30 |
Deconvoluting the role of Glycogen synthase kinase-3 in embryonic stem cellfate decisions using a chemical genetic approach |
Melanie J. Welham (Bath, UK) |
16:00 |
Slow cycling cells in pancreas adenocarcinoma as potential drug targets |
Stefan Krauss (Oslo, Norway) |
16:30 |
Coffee break |
| 16:45 Poster session II - National Networks |
17:45 |
Bus Transfer to hotels |
19:20 |
Meeting point - Charles Bridge Museum |
19:30 |
Welcome drink / Final remarks / Closing / Poster Awards |
20:30 |
Conference dinner - Boat Nepomuk |
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