ecbs
Organised by:
euopenscreen
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Supported by:
CCG
FMP
CeMM
Media partners:
Nature Chem. Biol.
Wiley
ACS Chem. Biol.

Programme

Thursday, 20 May 2010
07:30
Bus Transfer from hotels
08:00
Registration
08:40
Opening
Session 1        Chemical Biology in Europe and beyond (J. Quintana & K. Tasken)
08:45
Keynote lecture
NIH Molecular Libraries Program: Integrative Technologies Enabling Biology and Chemistry as a Public Resource for Translational Research
James Inglese (Bethesda, USA)
09:30
Academic screening, challenges and new opportunities
Phil Gribbon (Hamburg, Germany)
10:00
Approaches to Drug Discovery for Tropical Diseases
Ian Gilbert (Dundee, UK)
10:30
Chemical Biology of Protein-Protein Interactions: Challenges and Opportunities
Joe Lewis (Heidelberg, Germany)
11:00
Coffee break
Session 2        Chemical chaperones and Protein Aggregation (R. Frank & M. Hibert)
11:30
Keynote lecture
Small molecule compounds: novel therapeutics for genetic diseases due to misfolding?
Peter M.T. Deen (Nijmegen, Netherlands)
12:15
Biased agonists pharmacochaperones of the V2 vasopressin receptor as potential therapeutic agents for nephrogenic diabetes insipidus
Christiane Mendre (Montpellier, France)
12:45
Two unrelated antiprion drugs isolated using a yeast-based assay are specific inhibitors of Ribosome-borne Protein Folding Activity (RPFA)
Marc Blondel (Brest, France)
13:15
Chemical Chaperones Modulate Protein Misfolding Pathways in Neurodegenerative Diseases
Erich Wanker (Berlin, Germany)
13:45
Lunch
Session 3         New Challenges and Avenues (T. Nielsen & O. Kallioniemi)
14:45
Keynote lecture
Drugging the cancer genome: Chemical probes and drugs in the clinic
Paul Workman (London, UK)
15:30
Chemical probes for systems biology
Jordi Mestres (Barcelona, Spain)
16:00
How to turn a protein kinase ON and OFF using the same switch: High resolution complex structure and allosteric effects of low molecular weight activators on the protein kinase PDK1 (selected from abstracts)
Ricardo M. Biondi (Frankfurt, Germany)
16:15
A boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation (selected from abstracts)
Huib Ovaa (Amsterdam, Netherlands)
16:30
Prospects and Challenges in Open Source Drug Discovery: Strategies to Conquer the Valley of Death (selected from abstracts)
Rathnam Chaguturu (Kansas, USA)
17:00       Poster and Czech beer session & BBQ
Friday, 21 May 2010
8:30
Bus Transfer from hotels
Session 4         Protein modifications (G. Superti-Furga & A. Levitzki)
09:00
Keynote lecture
The interplay between phosphorylation and ubiquitylation in regulating innate immunity
Sir Philip Cohen (Dundee, UK)
09:45
Molecular targets, mechanisms and opportunities for combination therapies of multi-targeted kinase inhibitors
Uwe Rix (Vienna, Austria)
10:15
Open Access Chemical Probes for Epigenetic Proteins
Tom Heightman (Oxford, UK)
10:45
EGFR receptor guided delivery of long chain dsRNA
Alex Levitzki (Jerusalem, Israel)
11:15
Coffee break
Session 5         New Challenges and Avenues (T. Nielsen, O. Kallioniemi)
11:45
Combinatorial Chemistry for the Chemical Biology of the GPCR's
Morten Meldal (Copenhagen, Denmark)
12:15
Chemical and Biological Diversity: New Approaches to Synthesising Bioactive Small Molecules
Adam Nelson (Leeds, UK)
12:45
Small molecules as inhibitors of Interleukin 8 expression (selected from abstracts)
Marc Reboll (Braunschweig, Germany)
13:00
Synthetic Mimicry of Protein Binding Sites for the Exploration and Modulation of Protein-Protein Interactions (selected from abstracts)
Jutta Eichler (Braunschweig, Germany)
13:15
Lunch
Session 6         Stem cell biology (P. Bartunek, K. Wennerberg )
14:15
Keynote lecture
Chemical Biology and Zebrafish
Leonard I. Zon (Boston, USA)
15:00
Targeting chromatin for transdifferentiation in the pancreas
Stefan Kubicek (Cambridge, USA)
15:30
Deconvoluting the role of Glycogen synthase kinase-3 in embryonic stem cellfate decisions using a chemical genetic approach
Melanie J. Welham (Bath, UK)
16:00
Slow cycling cells in pancreas adenocarcinoma as potential drug targets
Stefan Krauss (Oslo, Norway)
16:30
Coffee break
16:45       Poster session II - National Networks
17:45
Bus Transfer to hotels
19:20
Meeting point - Charles Bridge Museum
19:30
Welcome drink / Final remarks / Closing / Poster Awards
20:30
Conference dinner - Boat Nepomuk